· Destination – to the nucleus. Activates transcriptional factor à binds to DNA and either activating or inhibiting one or more genes.
· Activation of genes à create new mRNA à new protein (genomic effect on the target cells)
· Exception: Estrogen and aldosterone à have cell membrane receptors linked to signal transduction pathways (like peptide hormones). These receptors enable those hormones to initiate rapid non-genomic responses in addition to their slower genomic effect.
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